RESEARCH

My broad research experience covers fundamental coordination chemistry to contemporary organic chemistry, drug discovery, chemical biology, and genomics. My graduate research objective was judicious template design to reach out to the selective remote C−H bond of arenes. The completely unexplored para-C−H bond activation has been achieved by judicious designing of nitrile-containing biphenyl silyl-based templates. Moreover, the strong coordinating pyrimidine-based template has been gradually developed to replace the weak coordinating nitrile group for more robust and diverse meta-functionalizations. My first postdoctoral research objective was the design and de novo synthesis of pseudo-natural products (PNPs) with the anticipation of novel bioactivity. A unique strategy of diverse-PNP scaffolds from a common divergent intermediate has been contemplated, which led to the identification of four novel chemotypes for Hedgehog signaling inhibition, tubulin modulation, DNA synthesis inhibition, and de novo pyrimidine biosynthesis inhibition through phenotypic screening and morphological profiling. At present, I am working on (1D & 3D)-mapping of drug binding to chromatin in cells.